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张晾

2015年11月12日 15:39  点击:[]

简介:

张晾,男,1979年6月生,5357cc拉斯维加斯副教授。2009年毕业于山东师范大学细胞生物学专业,获理学博士学位。多年来一直从事心血管疾病发病机制的研究。先后主持国家自然科学基金、教育部博士学科点专项科研基金、山东省优秀中青年科学家科研奖励基金等项目,参与过多项国家自然科学基金项目、省自然科学基金和省科技攻关项目。近几年围绕动脉粥样硬化与血管损伤引起的血管增生性疾病的发病机理开展相关研究,主要研究方向为:1)巨噬泡沫细胞与血管平滑肌细胞间物质与信息交流;2)血管平滑肌细胞表型转换与增殖迁移的调控机理。围绕该领域发表SCI收录论文10余篇,曾获山东高等学校优秀科研成果奖(自然科学类)三等奖、校级优秀教学奖、教育实习优秀指导教师等荣誉称号。培养毕业硕士研究生1人,获得校级优秀硕士学位论文,在读硕士研究生4人。


承担的主要项目:

1.国家自然科学基金(81100193):巨噬泡沫细胞源外泌体中microRNA促血管平滑肌细胞增殖的机制研究。2012.01-2014.12。主持人

2.教育部高等学校博士学科点专项科研基金新教师类(20113704120006):TNFα在巨噬细胞源胆固醇逆转运中的作用机制研究。2012.01-2015.12。主持人

3.山东省优秀中青年科学家科研奖励基金(BS2013YY043):miRNA-181a在PDGF-BB诱导血管平滑肌细胞增殖迁移中的作用机制研究。2013.10-2016.10。主持人

4.国家自然科学基金(81070685):TNF-α与Wnt及chemerin信号通路串话在脂肪细胞分化中的作用机制研究。2011.01-2013.12。主要参与人


主要科研成果:

1.Liang Zhang, Yanyan Zhang, Lingmin Ye, Jie Pan.Effect of polyunsaturated fatty acids on the metabolism of apoB100-containing lipoproteins in apolipoprotein E deficient mice. Prog Biochem Biophys. 2015; 42(9):843-849.

2. Maolei Gong, Chuanguo Liu,Liang Zhang, Hongbin Zhang, Jie Pan. Loss of the TNFα function inhibits Wnt/β-catenin signaling, exacerbates obesity development in adolescent spontaneous obese mice. Mol Cell Biochem. 2014; 391(1-2): 59-66.

3. Yuying Zhang,Liang Zhang*, Yue Geng, Yunhong Geng. Hawthorn fruit attenuates atherosclerosis by improving the hypolipidemic and antioxidant activities in apolipoprotein e-deficient mice. J Atheroscler Thromb. 2014; 21(2): 119-128.(并列第一兼通讯作者)

4. Tao Guo,Liang Zhang, Dong Cheng, Tao Liu, Liguo An, Weiping Li, Cong Zhang. Low-density lipoprotein receptor affects the fertility of female mice. Reprod Fertil Dev. 2014. doi: 10.1071/RD13436. [Epub ahead of print]

5. Ting Zhang, Pengyuan Dai, Dong Cheng, Liang Zhang, Zijiang Chen, Xiaoqian Meng, Fumiao Zhang, Xiaoying Han, Jianwei Liu, Jie Pan, Guiwen Yang, Cong Zhang. Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. Reproduction. 2013; 147(2):141-151.

6. Yanrong Sun, Miao Yin,Liang Zhang, Jie Pan. Characterization of the cytokine expression profiles of the aorta and liver of young tumor necrosis factor alpha mutant mice. Mol Cell Biochem.2012; 366(1-2):59-67.

7.Shun Zhang, Xu Wang,Liang Zhang, Xiaolei Yang, Jie Pan and Guocheng Ren. Characterization of Monocyte Chemoattractant Proteins and CC Chemokine Receptor 2 Expression During Atherogenesis in Apolipoprotein E-null Mice.J Ather Throm. 2011; 18(10):846-856.

8.Liang Zhang, Yue Geng, Ning Xiao, Miao Yin, Guocheng Ren, Liufeng Mao, Shun Zhang, Jie Pan. Dietary low n-6/n-3 polyunsaturated fatty acid ratios decrease C-reactive protein expression in apolipoprotein E-null mice.Nutrition.2010; 26:829-834.

9.Miao Yin,Liang Zhang, Xiaoming Sun, Liufeng Mao, Jie Pan. Lack of apoE causes alteration of cytokines expression in young mice liver.Mol Biol Rep. 2010; 37:2049-2054.

10.Liang Zhang, Yue Geng, Ning Xiao, Miao Yin, Liufeng Mao, Guocheng Ren, Cong Zhang, Peng Liu, Nannan Lu, Liguo An, Jie Pan. High dietary n-6/n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice.J Ather Throm.2009; 16(4):463-471.

11.Ning Xiao, Miao Yin,Liang Zhang, Xuebin Qu, Hui Du, Xiaoming Sun, Liufeng Mao, Guocheng Ren, Cong Zhang, Yue Geng, Liguo An, Jie Pan.Tumor necrosis factor-alpha deficiency retards early fatty-streak lesion by influencing the expression of inflammatory factors in apoE-null mice.Mol Genet Metab.2009; 96:239-244.

12.YanyanZou, HuiDu, MiaoYin,LiangZhang, LiufengMao, NingXiao, GuochengRen, CongZhang, JiePan.Effects of high dietary fat and cholesterol on expression of PPARα, LXRα and their responsive genes in the liver of apoE and LDLR double deficient mice.Mol Cell Biochem.2009; 323(1-2):195-205.